异基因造血干细胞移植术后发生甲状腺功能亢进1例报告并文献复习

摘要

Objective To investigate the characteristics of diagnosis and treatment on hyperthyroidism after allogeneic hematopoietic stem cell transplantation (AHSCT).Methods The clinical data of a female patient who suffered from hyperthyroidism after AHSCT at Department of Hematology of the Third Affiliated Hospital,Sun Yat-sen University at December 2008 were analyzed retrospectively.The clinical manifestation,laboratory examination,diagnosis and treatment of the patient were summarized and analyzed, and the relevant literatures were reviewed.Results The patient developed the symptoms of hyperthyroidism at 39 months after AHSCT,and had the clinical manifestation and laboratory examination results specific to hyperthyroidism.The patient was diagnosed as diffuse toxic goiter (Graves’disease)and had good prognosis after drug therapy.Conclusions It is rare to develop hyperthyroidism after AHSCT that has specific clinical manifestation and can be confirmed by laboratory examination.Graves'disease has good prognosis with early diagnosis and treatment.%目的：探讨异基因造血干细胞移植术后发生甲状腺功能亢进（甲亢）的诊治特点。方法回顾性分析2008年12月在中山大学附属第三医院血液科行异基因造血干细胞移植术后发生甲亢的1例女性患者的临床资料，总结分析该例患者的临床表现、实验室检查以及诊治经过，并复习相关文献。结果该患者异基因造血干细胞移植术后39个月出现甲亢症状，患者有甲亢特异性临床表现和实验室检查结果，诊断为弥漫性毒性甲状腺肿（Graves 病），给予药物治疗后效果良好。结论异基因造血干细胞移植术后发生甲亢临床少见，有特异性临床表现，确诊主要依靠实验室检查。该病如早期诊断和治疗，疗效良好。