幽门螺杆菌感染与胃癌患者临床特征和生存状况的关系研究

摘要

Objective To explore the correlation between helicobacter pylori (HP) infection and the clinical charac-teristics and survival status of patients with gastric cancer. Method 80 cases of gastric cancer patients were included in the study, and were stratified as infection group (n=52) or non-infection group (n=28) as per patients’HP infection sta-tus, and patients in HP infection group were further divided into three subgroups of A, B, and C according to respective virus load, and then the clinical features and survival of the four groups were compared. Result The age, lymph node metastasis, Lauren classification, local infiltration of the four groups were of statistically significant differences (P<0.05). Group C had more patients with lymph node metastasis at N2 and N3 than the other three groups, while more N0 and N1 cases were observed in non-infection group;A higher proportion of intestinal type and more local infiltration of T3, T4 were observed in group C than the other groups; Infection group had more patients with gastric antral cancer, while non-infection group had more gastric cancer located at fundus, with significant differences observed (P<0.05). Pa-tients in non-infection group had significantly longer average survival period than that of the infection group (P<0.05), and as the HP infection load increased, patients’survival were decreased. Cox regression analysis showed that, HP in-fection, lymph node metastasis, age (>60 years old), gastric antral cancer, depth of invasion were independent risk fac-tors associated with survival status of patients with gastric cancer, with statistical significance observed (P<0.05). Con-clusion HP infection is associated with the clinical characteristics of gastric cancer patients, and higher virus load is relevant with worse survival.%目的：探究幽门螺杆菌（HP）感染与胃癌患者临床特征和生存状况的关系。方法选择就诊的80例胃癌患者，根据患者是否发生HP感染分为感染组患者52例和未感染组患者28例，根据感染组患者的HP感染量又将患者分为A、B、C三组，比较四组患者的临床特征和生存状况。结果四组患者的年龄，淋巴结转移，Lauren分型，局部浸润方面比较，差异均有统计学意义（P﹤0.05）。C组患者淋巴结转移N2期和N3期例数多于其他三组，而未感染组N0、N1期例数较多；C组患者Lauren分型中肠型比例，局部浸润T3、T4期比例大于其他三组；感染组患者胃窦癌比例较大，未感染组患者中胃底癌比例较大，差异均有统计学意义（P﹤0.05）。对照组患者的平均生存期大于感染组，差异具有统计学意义（P﹤0.05），且感染组患者中HP感染量越大患者生存期越短。Cox回归分析显示，HP感染，淋巴结转移，年龄（﹥60岁），胃窦癌，浸润深度均是影响胃癌患者生存状况的独立危险因素，具有统计学意义（P﹤0.05）。结论 HP感染与胃癌患者的临床特征有关，且HP感染量越大患者的生存状况越差。