FOXP1在弥漫性大B细胞淋巴瘤患者体内表达及其临床意义分析

摘要

Objective To observe the expression of FOXP1 in the serum of patients with diffuse large B cell lympho-ma (DLBCL) and to analyze its clinical significance. Method 80 patients with DLBCL(study group), and 80 healthy adults(control group)were synchronously included in the study,the FOXP1 expression in serum of the two groups were observed and compared to analyze the factors influencing FOXP1 expression.Result The positive rate of FOXP1 ex-pression in study group was 70.0%,which was significantly higher than that in control group at 20.0%,with statistically significant difference observed(χ2=46.582,P<0.01).In study group,patients aged≥65 years old,with stage III+IV dis-ease,C-reactive protein(CRP)≥10 U/L,and with international prognostic index(IPI)as high risk,and who were symp-tomatic had significantly higher positive expression of FOXP1 than those aged<65 years,with stage I+II disease,CRP<10 U/L,IPI of low or moderate risk and who were asymptomatic,the differences were statistically significant(P<0.01), however,there was no significant difference observed between male and females(P>0.05);factors with clinical signifi-cance in univariate analysis,including age,stage,CRP,IPI and with or without symptoms were included as independent variables,and the positive expression of FOXP1 in patients with DLBCL was taken as dependent variable for multivariate Logistic regression analysis,and it was found that stage III+IV and IPI as high risk were included in the regression equa-tion(OR=4.416,4.879,P<0.01).Conclusion FOXP1 was highly expressed in patients with diffuse large B cell lympho-ma,and the staging as well as the risk level of IPI are the factors that affect thei expression.%目的 观察FOXP1在弥漫性大B细胞淋巴瘤(DLBCL)患者血清中的表达情况,并分析其临床意义.方法 选取80例DLBCL患者(观察组)和80例同期体检的健康成年人(对照组),观察两组受试者血清FOXP1的表达情况,比较不同临床特征DLBCL患者的FOXP1表达差异,分析DLBCL患者FOXP1表达的影响因素.结果 观察组患者的FOXP1阳性表达率为70.0%,明显高于对照组受试者的20.0%,差异有统计学意义(χ2=46.582, P﹤0.01).观察组年龄≥65岁、Ⅲ+Ⅳ期、C反应蛋白(CRP)≥10 U/L、淋巴瘤国际预后指数(IPI)高危、有症状患者的FOXP1阳性表达率明显高于年龄﹤65岁、Ⅰ+Ⅱ期、CRP﹤10 U/L、IPI中低危、无症状者,差异均有统计学意义(P﹤0.01),而不同性别患者的FOXP1表达比较,差异无统计学意义(P﹥0.05);将单因素分析有意义的年龄、临床分期、CRP、IPI是否高危、有无症状作为自变量,将DLBCL患者FOXP1阳性表达作为因变量,进行多因素Lo-gistic回归分析,结果临床分期Ⅲ+Ⅳ期和IPI高危进入回归方程(OR=4.416、4.879,P﹤0.01).结论 FOXP1在DLBCL患者体内表达水平较高,且与分期情况和IPI是否高危有关.