血清胱抑素C与妊娠期糖尿病早期肾损害的相关性

摘要

Objective To investigate the correlation of Serum Cystatin C(CysC) with early renal damage of Gestational Diabetes Mellitus (GDM), and to study the application value of CysC in early renal damage of GDM. Method 91 cases were selected as the research objects (GDM Group), who were checked regularly and diagnosed clearly as GDM from August 2010 to January 2013 in our hospital, 90 cases of normal pregnant woman were selected in the same period for control group. For all the pregnant women the microamount CysC, Glycosylated hemoglobin, blood urea nitrogen(BUN), creatinine (Scr) and urine microalbumn(mALB) were measured and statistically analyzed. Results The levels of CysC and Glycosylated hemoglobin and mALB in GDM group were significantly higher than those of control group(P=0.000, P=0.001, P=0.000), the levels of BUN and Scr had no significant difference between these two groups (P>0.05). CysC was correlated positively with Glycosylated hemoglobin and mALB seperately in the GDM group (P=0.001, P=0.000). But CysC had no correlation with those in control group (P>0.05). Conclusions The increase of CysC level is related closely to the early renal damage of GDM. CysC plays an important role to diagnose the early renal damage and evaluate the progression of GDM.%目的：探讨血清胱抑素C与妊娠期糖尿病（Gestational Diabetes Mellitus, GDM）早期肾损害的相关性，研究血清胱抑素C在妊娠期糖尿病早期肾损害诊断的价值。方法选取2010年8月~2013年1月于我院进行定期产检明确诊断为GDM并符合入选标准者91例为研究对象（GDM组），选取同期的90名正常妊娠孕妇为对照组，检测两组孕妇的血清胱抑素C、糖化血红蛋白、血尿素氮（BUN）和血肌酐（SCr）及尿微量白蛋白（mAlb），并进行统计分析。结果 GDM组血清胱抑素C、糖化血红蛋白及尿微量白蛋白均较对照组明显升高，两组比较有显著统计学差异（P=0.000，P=0.001，P=0.000）；但血尿素氮、血肌酐在两组比较差异无统计学意义（P>0.05）。GDM组中血清胱抑素C分别与糖化血红蛋白、尿微量白蛋白呈正相关（P=0.001，P=0.000），正常妊娠组中血清胱抑素C与各指标检测值无相关性（P>0.05）。结论血清胱抑素C水平的升高与妊娠期糖尿病早期肾损害的有密切相关，对早期肾损害的诊断及病情的评估有重要的作用。