Objective To observe the preventive effect of Swertia macrosperma extracts on acute alcohol-induced liver injury . Methods The test of ataxia function was performed to evaluate the anti-alcoholism and drunkenness prevention effect .Mean-while ,the ALT and hepatic glycogen were determined .Results The Swertia macrosperma ethanol extracts can significantly ex-tend the time of the mice drunken ;The time of regaining the right reflex for the medicated group was shorter than that of the con-trol group;the number of drunk mice after treatment was significantly reduced than that of the non-administered group .Conclu-sion Swertia macrosperma extracts have protective effects on acute alcohol-induced liver injury .%目的:对大籽獐牙菜乙醇提取物在解酒保肝方面的作用进行初步研究探讨。方法采用纠正运动失调作用实验、解酒实验和预防醉酒实验,同时测定急性酒精性肝损伤小鼠的血清丙氨酸转换酶(ALT)和肝糖原的含量。结果大籽獐牙菜醇提取物可显著延长小鼠酒后在网停留时间;使给药组的翻正反射恢复时间较对照组显著缩短;给药后醉酒小鼠数较未给药组显著减少;可对抗乙醇对小鼠肝脏造成的损伤,使谷丙转氨酶活力显著下降,促进肝糖原的分解,对抗乙醇造成的低血糖。结论大籽獐牙菜提取物具有纠正运动失调、解酒以及预防酒醉作用,其对乙醇所致的肝损伤有防治作用。
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