Objective To screen the main antitumor activity of four extracts of Euphorbia ebracteolata in vitro .Methods The four extracts obtained from E .ebracteolatawere evaluated for their cytotoxic activity against SMMC-7721 ,HeLa ,HepG2 and H460 by using MTT assay .Results Extracts of E .ebracteolatashowed potential antiproliferative activity against the four cell lines applied in different degree .Among the four extracts ,petroleum ether extract of processed E .ebracteolata showed the highest activity with inhibition ratio(IR) of 81 .08% ,80 .39% and 89 .81% against SMMC-7721 ,HepG2 and H460 ,respectively .And IR of ethyl ace-tate extracts of processed E .ebracteolata were 79 .06% ,78 .36% and 67 .33% ,respectively .Conclusion Petroleum ether extracts and ethyl acetate extracts are proved to be the effective anticancer agents in vitro .%目的：对从狼毒中分离得到的4种提取物进行体外抗肿瘤活性筛选。方法采用四甲基偶氮唑盐法研究狼毒提取物对SMMC-7721、HeLa、HepG2、H4604种人癌细胞株增殖的影响。结果狼毒提取物可以不同程度地抑制4种人癌细胞株的增殖。其中炮制品石油醚部位抑制作用最强，对 SMMC-7721、HepG2、H460细胞株增殖抑制率分别为81．08％，80．39％和89.81％；炮制品乙酸乙酯部位的抑制率分别为79．06％，78．36％和67．33％。结论狼毒炮制品石油醚部位和乙酸乙酯部位是狼毒抗肿瘤作用的主要活性部位，值得进一步深入探讨和研究。
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