采用色谱手段从美洲大蠊中分离得到22个化合物,利用波谱解析鉴定了它们的结构,分别命名为甘油(1)、邻羟基苯甲酸(2)、苯丙氨酸(3)、色氨酸(4)、尿嘧啶(5)、腺嘌呤(6)、环(脯氨酸-苏氨酸)(7)、环(脯氨酸-丙氨酸)(8)、环(丙氨酸-缬氨酸)(9)、环(甘氨酸-异亮氨酸)(10)、环(甘氨酸-亮氨酸)(11)、腺嘌呤核苷(12)、次黄嘌呤核苷(13)、环(亮氨酸-丝氨酸)(14)、环(丝氨酸-苯丙氨酸)(15)、环(天冬酰胺-苯丙氨酸)(16)、环(酪氨酸-甘氨酸)(17)、环(酪氨酸-丙氨酸)(18)、环(酪氨酸-丝氨酸)(19)、环(酪氨酸-苏氨酸)(20)、环(酪氨酸-天冬氨酸)(21)和Cordyrrole A (22).其中,化合物7～n、14～22为首次从美洲大蠊中分离得到,而化合物20和21为新的天然产物.此外,对化合物抗一氧化氮生成作用和促血管生成活性进行了测试.%Twenty-twocompoundswere isolatedfrom Periplaneta americana.Their structures were identified as glycerol (1),salicylic acid (2),phenylalanine (3),tryptophan (4),uracil (5),adenine (6),cyclo (Pro-Thr) (7),cyclo (ProAla) (8),cyclo (Ala-Val) (9),cyclo (Gly-Ile) (10),cyclo (Gly-Leu) (11),inosine (12),adenosine (13),cyclo (Leu-Ser) (14),cyclo(Phe-Ser) (15),(3S,6S)-3-phenylmethyl-6-amidocarboxymethyl-piperazine-2,5-dione,cis-cyclo (Asn-Phe) (16),cyclo (Tyr-Gly) (17),cyclo (Tyr-Ala) (18),cyclo (Tyr-Ser) (19),cyclo (Tyr-Thr) (20),cyclo (Tyr-Asp) (21) andcordyrrole A (22),respectively,by spectroscopic methods.Compounds 20 and 21 are new naturally occurring substances.In addition,compounds 7-11 and 14-22 were isolated from the title insect species for the first time.In addition,biological evaluation towards nitric oxide (NO) production and angiogenesis activity was conducted.
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