神经振荡交叉节律耦合的生理学意义及在神经工程基础研究中的应用

摘要

Cross-frequency coupling ( CFC) of neural oscillations could support integration and exchange information across different temporal and spatial scales, playing an important role in facilitating neural communication and promoting neural plasticity.Particularly, phase-amplitude coupling ( PAC), one of the CFC patterns, relates to multi-item working memory maintenance and long-term memory retrieval. This review presents a comprehensive introduction of CFC phenomenon in neural oscillation systems, and expounds the correspondent physiological significance.In order to quantitatively measure the CFC, three commonly used algorithms are introduced and their applications in neurobiological studies are presented accordingly.Finally, a brief description of the CFC potential applications in the fundamental research of neural engineering is provided.%交叉节律耦合（ cross－frequency coupling，CFC）反映了不同时空尺度上信息的整合与交流，在神经信息通讯和促进突触可塑性等方面有重要作用。其中，相位－幅值耦合（ phase－amplitude coupling，PAC）与工作记忆中多重对象的维持以及长时程记忆的回忆过程相关。此综述较全面地介绍了神经振荡CFC现象，阐述了其对应的生理学意义，给出了量化分析CFC的3种常用算法及其应用，并简单描述了CFC在神经工程研究中的潜在应用。