Fuzheng Guben (FZGB) Chinese medicine, or tonification Chinese medicine, is widely used to treat various malignant tumors through activating the spleen and replenishing qi, nourishing yin and enriching the blood, warming yang and reinforcing kidney. Modern Chinese medicine pharmacological researches have demonstrated that this kind of anti-tumor herbs is able to control immunosuppressive factors related to anti-tumor immune and response in host, which plays an important role in anti-cancer treatment. However, most of the active ingredients from FZGB Chinese medicine have shortcomings such as difficult absorption and low bioavailability. Hence, the treatment effect is not satisfied. During the past few decades, novel drug delivery system has become a hot research topic for the development of FZGB Chinese medicine. This paper mainly focused on the new drug delivery system of FZGB Chinese medicine, especially five commonly used medicine, namely Ginseng, Angelica sinensis, Astragalus mongholicus, Lucid ganoderma, and Codonopsis pilosula. This study is aimed to offer more references and evidences for the development of new formulations in anti-tumor Chinese medicine.%扶正固本类中药可通过益气健脾、养阴补血、温阳补肾等方法,增强机体抗肿瘤的免疫功能,广泛应用于肿瘤的辅助治疗.现代中药药理研究表明,扶正固本类中药如麦门冬、玉竹、天门冬以及山茱萸等,主要是通过调控宿主抗肿瘤免疫应答相关的免疫抑制因子,从而发挥肿瘤的免疫治疗效果.然而,该类中药中的有效成分(多糖、皂苷等)多存在吸收困难、生物利用度低等缺陷,影响了其治疗效果.近年来,使用新型传递系统解决药物存在的溶解度、稳定性和不良反应等问题已成为该类中药研究开发的一大热点.本文主要对近几年来备受关注的几种新型抗肿瘤中药剂型,以及在肿瘤治疗方面比较常见的5种扶正固本类抗肿瘤中药包括人参、当归、黄芪、灵芝和党参等新型药物传递系统进行综述,旨在为该类抗肿瘤中药新剂型的研究与开发提供参考和依据.
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