目的:观察解毒通脉汤治疗闭塞性动脉硬化症的临床疗效。方法:选取246例闭塞性动脉硬化症患者中血脉瘀阻型患者,随机分成两组,对照组120例,患者常规口服拜阿司匹林0.1 g+辛伐他丁片20 mg ,每日一次;治疗组126例,患者在口服拜阿司匹林及辛伐他丁片的基础上,加服中药解毒通脉汤,8周后观察患者临床症状改善情况和臂踝指数(ABI)、超敏C反应蛋白(Hs-CRP)、持续经皮氧分压(TcPO2)变化。结果:与对照组相比,治疗组临床症状明显改善(P<0.05),患者ABI、CRP、TcPO2均有显著提高(P<0.01)。结论:解毒通脉汤对闭塞性动脉硬化症血脉瘀阻型患者治疗有效,间接验证了中医因邪致瘀理论的指导意义。%This study was aimed to observe the clinical efficacy of Jie-Du Tong-Mai (JDTM) decoction (i.e., detoxi-fication unclogg artery soup) of arteriosclerosis obliterans. A total of 246 arteriosclerosis obliterans cases with the pattern of blood stasis were selected and randomly divided into two groups. In the control group of 120 cases, 0.1 g of aspirin and 20 mg of simvastatin tablets were orally administrated, once a day. In the treatment group of 126 cas-es, JDTM decoction was combined on the basis of oral administration of aspirin and simvastatin tablets. After 8 weeks of treatment, observations were made on improvement of clinical symptoms and changes of ABI, Hs-CRP, TcpO2. The results showed that compared with the control group, clinical symptoms of the treatment group were obvi-ously improved (P< 0.05). And the ABI, CRP, TcpO2 were also obviously increased (P< 0.01). It was concluded that JDTM decoction was effective in the treatment of arteriosclerosis obliterans with the pattern of blood stasis. It al-so indirectly proved the guiding meaning of traditional Chinese medicine that evil causing stasis.
展开▼