Objective It is to observe the effects of Wenxiao granule on the blood fat metabolism in experimental atherosclerotic rabbits.Methods Thirty-six healthy New Zealand rabbits were chosen and their blood from ear veins was gotten to determine the levels of TC , TG, HDL - C, LDL - C before the experiment.Then the rabbits were randomly divided into blank group with 9 rabbits and model group with 27 rabbits, and were fed with normal diet and a high-fat diet respectively.After 8 weeks, the models were established successfully and their blood from ear veins were gotten again to determined the indexes above.Then the model group was divided into 3 groups: Wenxiao granule group simvastatin group and model control group.Thereafter, rats in two drug-treated groups were treated with respective drug according to their weight and fed with the standard food for another 8 weeks.At the end of experiment, all the rats were sacrificed and blood was collected for determining the concentration of the indexes above.Results Compared with hlank group, the levels of TC , TG and LDL - C decreased apparently in Wenxiao granule group, simvastatin group and atherosclerosis model group.Compared with model control group, the levels of TC and LDL - C were significantly lower than that in Wenxiao granule group, simvastatin ( P ＜0.05 ), but no significant difference was found among medication groups( P ＞0.05 ).HDL - C had an increasing tendency, but without statistical significance.Conclusion Wenxiao granule group could obviously low down the levels of TC ,TG , LDL - C , and improve blood fat metabolism disorder.%目的 观察稳消颗粒对兔实验性动脉粥样硬化血脂代谢的影响.方法 选取健康新西兰大白兔36只,实验前经耳缘静脉采血,检测总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,随机分为空白组9只和造模组27只,分别给予标准饲料和高脂饲料.8周后造模成功,经耳缘静脉采血,再次检测上述指标.将造模组随机分为3组:稳消颗粒组(稳消颗粒)、辛伐他汀组(辛伐他汀)、模型对照组(蒸馏水).停用高脂饲料,改用标准饲料并根据体质量比折算的临床剂量给予相应的药物治疗8周后,处死动物,检测上述指标.结果 与空白组相比,稳消颗粒组、辛伐他汀组和模型对照组的TC、TG、LDL-C水平显著增高.与模型对照组相比,稳消颗粒组、辛伐他汀组TC、TG、LDL-C的水平显著降低,但用药组之间比较没有显著性差异;HDL-C有增高的趋势,但各组比较均无显著性差异.结论 稳消颗粒可降低TC、TG、LDL-C水平,改善血脂代谢紊乱.
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