目的 探讨依达拉奉注射液对急性脑出血患者神经功能及血液细胞因子IL-1、IL-8、TNF-α水平的影响.方法 对126例首次发病且于起病24h内入院的急性脑出血患者分为治疗组及对照组,对照组予常规治疗,治疗组在对照组治疗的基础上加用依达拉奉.2组均于入院时、入院第7天、第14天采外周血测IL-1、IL-8、TNF-α,同时神经功能评分,并进行对比分析.结果 2组患者血清细胞因子IL-1,IL-8,TNF-α浓度均随病程逐渐增高,但治疗组升高幅度低于对照组,于14d时下降幅度明显大于对照组(P<0.05).治疗后2组神经功能缺损评分均降低,与治疗前比较均有显著性差异(P均<0.05),且治疗组明显优于对照组(P<0.05).结论 依达拉奉可以改善患者神经功能,通过减轻细胞因子介导的炎症反应对脑组织实施保护作用.%Objective It is to approach the influence of edaravone injection on neurological function in acute cerebral hemorrhage patients and the levels of blood cytokine interleukin - 1 ( IL - 1 ), interleukin - 8 ( IL - 8 ) and tumor necrosis factor -α ( TNF - α ).Methods One hundred and twenty-six patients with first onset and admitted within 24 h after the onset of acute cerebral hemorrhage were divided into treatment group and control group.The control group was treated with conventional therapy.The treatment group was treated with edaravone based on the treatment of control group.The peripheral blood in the two groups was collected on admission and after admission for 7 d and 14 d to detect the levels of IL - 1, IL - 8 and TNF - α, the neurological function was scored and the data in the two groups were compared and analyzed.Results The concentration of serum cytokines IL - 1 , IL - 8 , TNF - α heightened gradually with the course of disease.But the heightening extent in treatment group was lower than that in control group, the descent extent after 14 d was obviously larger than that in control group ( P ＜0.05 ).After treatment, the neurological function defective scores in the two groups were both lowered and the differences were both significant compared with that before treatment ( both P ＜ 0.05 ), and that in treatment group was obviously better than that in control group ( P ＜ 0.05 ).Conclusion Edaravone can improve neurological function of the patients and has protectiveeffect on brain tissue through lightening inflammatory reaction mediated by cytokine.
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