急性缺血性脑卒中患者CRP、TNF-α的变化及辛伐他汀抗炎作用研究

摘要

Objective It is to explore the relationship between inflammaiion and acute ischemic stroke and to explore the protecting effect of Simvastatin on cerebral injury. Methods 42 subjects with cerebral infarclion were randomly divided into two groups: group A with 17 cases and group B with 25 cases. In addition, 30 normal persons after a general health examination were chosen as control group ( group C ). Group A was treated with normal method, group B was given Simvastatin based on normal treatment. The levels of C reactive protein ( CRP ) and TNF -α of the three groups being hospital and those of group A and B after two weeks' treatment were determined, and the levels were compared among the patients of light, moderate and severe type. Results The level of CRP and TNF -α before treatment in group A and group B was significantly higher than those in group C. After two weeks' treatment, the levels of those factors in group A were also higher than that in the control group, the level of CRP in group B was lower than that of group A, but compared with the control group, the difference was not significant. The level of TNF -α in group B was significant higher than that in group C. The levels of CRP and TNF -αin light stroke group were significantly higher than those in control group. The level of CRP in medium stroke group was significantly higher than that in light stroke group, but the level of TNF -α had no significant difference between two groups. The level of CRP and TNF - α in light and moderate groups compared with serious group had significant difference. Conclusion Inflammation has a strong association with ischemic stroke and inflammation reaction is an important risk factor of ischemic stroke. Simvastatin not only has improving effect on blood fat, but also has anti-inflammation.%目的 探讨急性脑卒中与炎症反应的关系及辛伐他汀对脑损伤的保护作用.方法 将急性缺血性脑卒中患者42例随机分为2组:A组17例,B组25例.另选择30例健康体检者作为C组.A组给予常规治疗,B组在常规治疗基础上给予辛伐他汀治疗.检测3组入院时及A组、B组治疗2周后CRP、TNF-α水平,并比较轻、中、重型患者CRP和TNF-α水平.结果 A组、B组治疗前CRP、TNF-α水平明显高于C组.治疗2周后,A组CRP、TNF-α亦明显高于C组;B组CRP水平低于A组,与C组相比无显著性差异;B组TNF-α水平与C组相比有显著性差异.轻型脑卒中组CRP和TNF-α水平均明显高于C组;中型脑卒中组CRP水平明显高于轻型脑卒中组,TNF-α 2组无显著性差异;轻型脑卒中组、中型脑卒中组与重型脑卒中组CRP和TNF-α比较均有显著性差异.结论 炎症与急性脑卒中的发生具有明确的相关性,炎症反应是急性脑卒中发病的一个重要危险因素.辛伐他汀除有调节血脂作用外,还具有抗炎作用.