益气扶正活血化瘀中药干预糖耐量低减的临床研究

摘要

Objective It is to approach the distinction and effect between Chinese materia medica of benefiting qi for strengthening resistance ( BQSR ) and promoting blood circulation for removing blood stasis ( PBCRBS ) in reversing impaired glucose tolerance ( IGT ) to normal. Methods One hundred and fifty patients with IGT were divided into 5 groups as Group A and B of BQSR or PBCRBS and Group pioglitazone, there were 30 cases in each group. The corresponding Chinese traditional medicine was used in Groups A and the Chinese traditional medicine and pioglitazone were used in Groups B. Group pioglitazone was the group of contrast. The treatment cycle was 12 weeks. The relative indexes of glucose tolerance were detected before and after treatment. Results There were significant differences in 2hPG, HbAl c and FINS between before and after treatment ( P<0.05 or 0.01 ). There were significant differences in2hPG, HbAlc, FINS between Group B of PBCRBS and Group pioglitazone after treatment ( P <0.05 ). Conclusion The two kinds of Chinese traditional medicine have the effect to reverse IGT, the effect may be better in kinds of PBCRBS comparing to BQSR.%目的 探讨益气扶正活血化瘀中药逆转糖耐量低减(IGT)的作用及其差异.方法 150例IGT患者随机分为益气扶正A、B组,活血化瘀A、B组以及吡格列酮组5组,每30例,A组只用相应中药,B类除了中药外另加服吡格列酮,吡格列酮组作为对照.检测各组试验前后的相关指标,处理时间为12周.结果 各组干预前后餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹血浆胰岛素(FINS)比较均有显著性差异(P<0.05或0.01);活血化瘀B组干预后2hPG、HbA1c、FINS水平与吡格列酮组组间比较有显著性差异(P均<0.05).结论 益气扶正和活血化瘀中药均具有逆转IGT的作用,而活血化瘀可能强于益气扶正类中药.