腹腔镜下胆囊切除术与开腹胆囊切除术围手术期血液黏滞度及氧化应激变化分析

摘要

Objective It is to approach the change of bleed viscosity and oxidative stress reaction in surround operation pe-riod of laparoscopic cholecystectomy and open cholecystectomy,so as to understand the damage degree of laparoscopic and open operation to the body,and compare the clinical curative effect of laparoscopic and open operation. Methods 54 patients who received cholecystectomy were selected and divided into observation group and control group,the patients were treated with laparoscopic cholecystectomy in the observation group and with traditional laparotomy in the control group,the changes of blood viscous degrees and oxidative stress reaction on three days before surgery,and 3 days,7 days after the operation were observed and compared in two groups. Results There was no significant difference in blood viscosity and oxidative stress change between the both groups before surgery for 3 days(all P<0. 05). After treatment,the blood viscous degrees and oxi-dative stress were both higher than before the operation in two groups,and the value after surgery for 7 days were significantly higher than that after surgery for 3 days(all P <0. 05). The blood viscosity and oxidative stress changes in the observation group after surgery were lower than that in the control group(all P<0. 05). Conclusion The changes of blood viscous degrees and oxidative stress after treatment by laparoscopic cholecystectomy are significantly lower than that by open cholecystectomy. It also can be seen the damage and influence of laparoscopic cholecystectomy on the body is significantly smaller than the open cholecystectomy,postoperative recovery is better. These prove that the clinical curative effect of laparoscopic cholecystectomy in the treatment of gallbladder disease.%目的：探讨腹腔镜下胆囊切除术和开腹胆囊切除术患者围手术期血液黏滞度及氧化应激变化，从而了解腹腔镜下手术和开腹手术对机体的伤害程度，对比腹腔镜下手术和开腹手术的临床疗效。方法随机选取接受胆囊切除术患者54例分成观察组和对照组，观察组患者采用腹腔镜下胆囊切除手术治疗，对照组患者则采用传统的开腹切除胆囊方法治疗，观察对比2组患者手术前3d、手术后3d、手术后7d的血液黏滞度和氧化应激变化。结果2组患者手术前3 d 的血液黏滞度和氧化应激指标比较差异均无统计学意义（P 均>0.05）；经手术治疗后，2组患者的血液黏滞度和氧化应激指标均比手术前高，且手术后7 d的血液黏滞度和氧化应激指标明显高于手术后3 d（P 均<0.05）；观察组患者手术后3 d 和手术后7 d的血液黏滞度和氧化应激指标均低于对照组（P均<0.05）。结论腹腔镜下进行胆囊切除手术对机体的伤害和影响明显比开腹胆囊切除术小，术后恢复也好，证明腹腔镜下进行胆囊切除手术治疗胆囊疾病的临床疗效好，值得临床推广使用。