目的：比较糖皮质激素两种不同给药方式治疗婴幼儿哮喘急性发作临床疗效。方法：按照入院顺序随机将本院儿科收治的86例婴幼儿哮喘患儿分为吸入组、口服组各43例，常规治疗基础上分别给予布地奈德混悬液雾化吸入和醋酸泼尼松片口服，比较两组患儿治疗效果。结果：吸入组患儿临床控制率和总有效率均略微高于口服组，但两组间比较，差异无统计学意义(P ＞0.05)；吸入组患儿治疗3d 后嗜酸性粒细胞、IgE、IL-4水平均显著低于口服组，差异具有统计学意义(P ＜0.05)；两组患儿治疗3d 后 CD4+/CD8+水平比较，差异无统计学意义(P ＞0.05)；两组患儿治疗后临床症状消失时间比较，差异无统计学意义(P ＞0.05)。结论：糖皮质激素两种不同给药方式治疗婴幼儿哮喘急性发作疗效基本相似，但雾化吸入给药药效见效更迅速，改善嗜酸性粒细胞、IgE、IL-4等指标效果更佳。%Objective: To compare the clinical effect of two kinds of different methods in the treatment of acute exacerbation of asthma in infants and young children. Methods: 86 cases of infants and young children with asthma were divided into inhalation group and oral group with 43 cases in each group, on the basis of routine treatment were given budesonide suspension liquid atomization inhalation and prednisone acetate tablets and compared the effect. Results: The clinical control rate and total effective rate were slightly higher than those in the control group, but there was no significant difference. The levels of eosinophile granulocyte、IL-4 and IgE in the treatment group after 3d were significantly lower than those in the oral group, the difference was statistically significant (P<0.05). Comparison of CD4+/CD8+ levels in two groups after treatment with 3d ,the difference was not statistically significant (P>0.05). The difference of clinical symptoms disappeared was not statistically significant (P>0.05). Conclusion: Efficacy of two kinds are similar, but the efficacy of atomization inhalation is more rapid, and the improvement of eosinophils, IL-4, IgE and other indicators is better.
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