Objective: The objective of this study was to explore the correlation between CG (cystitis glandularis, CG) and BC(bladder cancer, BC) and investigate the canceration rate of CG. Methods: The patients diagnosed with CG for the first time and with complete readmission information from Jan 2006 to Dec 2016 were given tracing analysis and the canceration rate of CG was analyzed. The patients with CG were classified as non-canceration group and the patients who have already worsened into BC were classified as canceration group. The difference of age, gender, course of disease, toxic exposure and complication between two groups were compared and the factors with statistical difference were incorporated in Logistic multi-factors analysis and the factors affecting the CG into BC were summarized. Results:A total of 173 cases were selected in this study, of whom 21 cases were diagnosed with BC and the CG canceration rate was 12.14%. multi-factor analysis showed that the course of disease for more than 1 year, toxic exposure for over 1 year, intestinal epithelial type and bladder stones were the independent risky factors effecting CG canceration and the risk degree of these factors were over 10(P<0.05). Conclusions: The CG canceration rate is rather high, which is probably the middle segment that normal BC developed into. The patients with long term course of disease, toxic exposure, intestinal epithelial type and bladder stones are more likely to get BC, who should be given intensive treatment, close follow-up to detect the canceration in advance.%目的:探讨腺性膀胱炎(Cystitis glandularis,CG)与膀胱癌(Bladder cancer,BC)的关系,并调查CG的癌变率.方法 :追踪分析2006年1月至2016年12月首诊确诊为CG患者中复诊资料完整病例,分析其CG癌变率,并将单纯CG患者纳入未癌变组,将转化至BC者纳入癌变组,比较两组患者年龄、性别、病程、病理分型、毒物接触史、合并症等临床资料的差异,将存在统计学差异的因素纳入Logistic多因素回归分析,总结影响CG进展至BC的危险因素.结果:173例入组患者,共21例确诊BC,CG癌变率为12.14%.多因素分析结果,病程≥1年、毒物接触史≥1年、病理分型肠上皮型、合并膀胱结石是影响CG癌变的独立危险因素,且上述因素的危险度(OR)均超过10(P<0.05).结论:CG癌变率较高,可能是正常膀胱粘膜发展至BC的中间节段,且病程、毒物接触史较长及肠上皮型、合并膀胱结石者具有更高的BC发生风险,应予以积极治疗、密切随访,早期发现癌变.
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