Objective To investigate the efficacy of olanzapine in the treatment of senile dementia. Methods 98 cases of senile dementia patients were divided into two groups, 50 patients in research group were treated with olanzapine, 48 cases in control group were given risperidone. Results The to-tal effective rate of research group was 94.00%, the incidence rate of adverse reaction was 12.00%, to-tal effective rate of the control group was 68.75%, the incidence rate of adverse reaction was 33.33%. The research group has higher efficiency, lower incidence rate of adverse reaction. After treatment, PANSS score decreased more obviously, there was a significant difference between the two groups.(P<0.05). Conclusion Olanzapine in the treatment of behavioral and psychological symptoms of senile de-mentia, can achieve better curative effect, PANSS score decreased significantly.%目的：探讨奥氮平治疗老年痴呆患者的疗效。方法将98例老年痴呆症患者分为两组，研究组50例给予奥氮平治疗，对照组48例给予利培酮治疗。结果研究组总有效率为94.00%，不良反应发生率为12.00%，对照组总有效率为68.75%，不良反应发生率为33.33%，研究组研究组总有效率较高，不良反应发生率较低，治疗后PANSS量表评分下降更明显，两组差异有统计学意义（P＜0.05）。结论奥氮平治疗老年痴呆患者精神行为症状，可取得较好的疗效，PANSS量表评分下降明显。
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