结肠癌患者血浆D-二聚水平的临床特点分析

摘要

目的：探讨血浆D-二聚体在结肠癌诊断中的临床意义。方法以48例结肠癌患者为观察组，35例结肠息肉为疾病对照组，体检中心体检的健康人48例为健康对照组，观察三组受检者D-二聚体水平，ROC曲线分析D-二聚体诊断结肠癌的诊断效能。结果观察组D-二聚体含量为0.929±0.433，与疾病对照组0.140±0.064，健康对照组0.136±0.063比较，差异有统计学意义P<0.05，P=0.00)。ROC曲线下面积(AUC)=0.983，与0.5相比较，差异有统计学意义(P<0.001)；最佳诊断分界点为0.24，敏感度为93.75%，特异度为98.8%。结论 D-二聚体含量与结肠癌的发病有密切的联系，可以用于结肠癌的辅助诊断。%Objective To explore the clinical significance of plasma D- dimer in the diagnosis of colon cancer.Methods 48 cases of patients with colon cancer in our hospital was chosen as the observation group,35 cases of patients with colon polyps as disease control group,48 cases of healthy people accepting health examination in medical examination center of as healthy control group,and the D- dimmer levels of three groups of subjects was observed,ROC curve was used to analyze D-dimer diagnostic efficiency for colon cancer.Results The D-dimer content of the observation group is 0.929±0.433,the disease control group is 0.140±0.064,and the healthy control group is 0.136±0.063;the difference is statistically significant (F=133.038,P=0.00). The area under the ROC curve (AUC) is 0.983,compared with the 0.5,the difference was statistically significant (z=48.271,P<0.05);the best diagnostic cutoff point was 0.24,when the sensitivity is 93.75%and the specificity was 98.8%. Conclusion D-dimer levels are closely linked with the incidence of colon cancer,and it can be used to assist in the diagnosis of colon cancer.