幼年社会隔离对大鼠成年后行为表征的影响

摘要

Objective To investigate rats reared in social isolation as a model of behavioral symptoms of neurodevelop-mental psychiatric disorders including schizophrenia.Methods Male rat pups were housed in individual cages from post-weaning to adulthood.Locomotor activity detection, Morris water maze test and social interaction test were performed. Results Compared with controls, the social isolation-reared rats got more body mass, showed locomotor hyperactivity and increased social interaction, but significant spatial learning changes were not observed in Morris water maze test.Conclu-sion Exposing rats to social isolation can profoundly affect behavior in adulthood, which can be used to build animal mod-els of neurodevelopmental psychiatric disorders including schizophrenia.%目的：考察社会隔离饲养大鼠模拟精神分裂症等神经发育性精神疾病的行为表征变化。方法自断乳起单笼饲养雄性大鼠幼仔至成年，依次进行自发活动检测、Morris水迷宫实验和社会交往实验。结果与对照比较，社会隔离饲养的大鼠表现出体质量增加、自发活动亢进以及社会交往增多等行为学改变，但在Morris水迷宫实验中没有表现出空间学习记忆的明显变化。结论大鼠幼年时的社会隔离饲养对动物成年后的行为产生深刻影响，可用来建立精神分裂症等神经发育性精神疾病的动物模型。