不同品系小鼠在禁食和（或）禁水情况下血糖变化特点的比较分析

摘要

Objective To provide reference on the difference in blood glucose metabolism between different mouse strains by comparing blood glucose changes under food and /or water deprivation.Methods C57BL/6J mice, BALB/c mice,and ICR mice used in this study were divided into four groups:control group, food deprivation group, water depriva-tion group and food &water deprivation group .Their blood glucose was measured within 12 hours under various stresses . Results and Conclusion There are different blood glucose regulation patterns in different mice strains .The blood glucose level of C57BL/6J mice is usually higher than that of the BALB/c and ICR mice, while the of blood glucose level BALB/c mice stays relatively stable , and the ICR mice have the widest range of blood glucose levels upon these stresses .Accord-ing to our data, the difference in blood glucose metabolism between different mouse strains should be taken into considera -tion in blood glucose related studies for proper interpretation and design of experiments .%目的：比较不同品系小鼠在禁食和（或）禁水情况下的血糖变化特点，为研究不同品系动物血糖代谢水平的差异提供参考依据。方法选择C57BL/6J小鼠、BALB/c小鼠、ICR小鼠作为研究对象，进行禁食和（或）禁水胁迫压力测试，分为正常进食进水组、禁食不禁水组、禁水不禁食组和禁食禁水组共4组，测定胁迫压力后12 h内血糖的变化。结果与结论3种品系小鼠血糖变化趋势有所差异，其中C57BL/6J小鼠整体血糖浓度高于BALB/c和ICR小鼠，BALB/c小鼠的血糖变化相对较为平稳，而ICR小鼠的血糖变化幅度最大。结果提示在进行血糖代谢相关研究中，需同时考虑不同品系动物血糖代谢能力差异，从而选择合适的动物进行研究并对数据进行合理分析和解释。