补体5a与急性肺损伤关系研究进展

摘要

急性肺损伤（ ALI）是多种原因诱发的肺部过度炎症反应，其发病率和死亡率均较高。由于其发病机制复杂且并未完全阐明，至今仍无特效救治药物。许多研究表明补体活性成分补体5a（ C5a）及其受体的激活在ALI的发生过程中是必需的，以C5a及其受体作为靶点的药物研发有望为ALI的治疗带来新的希望。该文对C5a参与ALI的实验证据和可能的作用机制进行了综述。%Acute lung injury ( ALI) is a type of pulmonary excessive inflammation with high morbidity and mortality.It can be induced by multiple causes.There are currently no successful therapeutic or preventive measures because the patho-genesis of ALI has not been completely clarified.Many studies have shown that the activation of complement 5a (C5a) and its receptors is necessary in the process of ALI.Drug development targeting on C5a and its receptors may bring new hope to the treatment of ALI.In this article, the experimental evidence and possible mechanisms are summarized to reveal the rela-tionship between C5a and ALI.