肠易激综合征患者应用双歧杆菌四联活菌联合谷维素治疗的疗效观察

摘要

目的：探讨肠易激综合征患者应用双歧杆菌四联活菌联合谷维素治疗的效果。方法采用随机分组的方法，将本院接收的384例肠易激综合征患者分为对照组和实验组，每组各192例。其中对照组给予匹维溴胺及谷维素口服，实验组在对照组治疗的基础上加用双歧杆菌四联活菌口服，分别观察比较分析两组患者治疗前后精神评分、消化道症状评分、治疗效果及不良反应发生情况。结果治疗后两组患者各亚型焦虑量表、抑郁量表评分及消化道症状评分均低于治疗前（P＜0．05）；实验组各亚型治疗后焦虑量表评分、抑郁量表评分及消化道症状评分均显著低于对照组（ P＜0．05）。对照组总有效率为71．88％，实验组总有效率为90．63％，其中腹泻型及腹泻便秘交替型，实验组明显高于对照组（P＜0．05）。两组均有患者出现轻微不良反应，对照组头痛、乏力4例，恶心2例，实验组头痛、乏力及恶心均有2例，经对症治疗后症状均消失。结论应用双歧杆菌四联活菌联合谷维素治疗肠易激综合征患者疗效显著，不良反应少，值得临床推广。%Objective To explore the effect of irritable bowel syndrome patients with application of bifidobacterium tetravac⁃cine tablets( live) and oryzanol. Methods 384 cases of patients with irritable bowel syndrome were selected and randomly divided into two groups. Control group gave pinaverium bromide and oryzanol, and the experimental group used bifidobacterium tetravaccine tablets ( live) on the basis of control group. Mental score, enteron symptom scores, therapeutic effect and adverse reactions were detected be⁃fore and after treatment and compared between two groups. Results After treatment, patients with anxiety scale, depression rating scale and the digestive tract symptom scores were lower than before treatment in the two groups ( P<0.05) . After treatment, anxiety rat⁃ing scale, depression rating scale and the digestive tract symptom scores of the experimental group were significantly lower than control group ( P<0.05) . The total effective rate of control group was 71. 88%, the experimental group was 90. 63%, and the experimental group was significantly higher than control group (P<0.05).Two groups had mild adverse reactions, and the control group had 4 cases with headache and weakness, 2 case with nausea;the experimental group had 2 case with headaches, fatigue and 2 case with nausea. The adverse reaction were disappeared after symptomatic treatment. Conclusion Irritable bowel syndrome patients with application of bifidobacterium tetravaccine tablets( live) joint oryzanol has obvious therapeutic effect, less adverse reactions, and it is worthy of clini⁃cal promotion.