To compare therapeutic effect of prostaglandin El in the patients with morning diabetic nephropathy, ninety-one patients with morning diabetic nephropathy were randomly divided into A group (who were treated with intravenous infusion of 10 microgram prostaglandin El perday for two weeks. ) and B group (who were treated with intravenous infusion of 20 micro-gram prostaglandin El perday for two weeks) finally. The changing of measurement results on ur-microalbun-min excretory rate for 8 hours ( UAER), serum urea nitrogen (BUN) and creatinine (Cr) were observed before and after treatment, the UAER,BUN and Cr of two groups dropped obviously P<0. 05, but the extent of the descent for the UAER were greater in B group than in A group and P<0. 001. The extent for the BUN were not different between B group and A group, the values of P were more than 0. 05(P>0. 05), the extent for the Cr were greater in B group than in A group P<0. 05. Prostaglandin El could decrease urine microalbumin and improve the renal function in the patients with morning diabetic nephropathy. The efficacy with 20 microgram prostaglandin El perday is better than 10 microgram.%比较不同剂量的前列腺素E1注射液在早期2型糖尿病肾病患者中的临床疗效.最终随机纳入91例早期2型糖尿病肾病患者,分别接受10μg/d(A组,n=47)与20μg/d(B组,n=44)的前列腺素E1治疗,2周后观察8小时尿微量白蛋白排泄率(UAER)、血尿素氮(BUN)和肌酐(Cr)的变化.结果显示,两组患者治疗后UAER、BUN、Cr均较治疗前明显下降,都具有统计学差异(P均<0.05),但A、B两组之间UAER下降幅度不一,B组较A组下降幅度更明显,具有统计学差异(P<0.001);两者之间BUN下降幅度相比没有统计学差异(P>0.05).两者之间的Cr下降幅度相比有统计学差异(P<0.05).由此推断,前列腺素El治疗早期糖尿病肾病,降低尿蛋白确实有效,而且前列腺素E1 20μg/d的剂量要比10μg/d降低尿蛋白效果更好.
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