基质金属蛋白酶-9与颈动脉粥样硬化斑块稳定性的关系

摘要

Objective To study the relationship between matrix metalloproteinase-9 and carotid atherosclerosis plaque’s stability. Methods The bilateral carotid atherosclerosis of 48 asymptomatic carotid atherosclerosis patients(ACA group) and 20 normal controls(NC group) were examined with color Doppler. The serum levels of MMP-9 in all the groups were measured by enzyme linked immunosorbent assay. Results Carotid atherosclerosis plaque was not found in NC group. The serum levels of MMP-9 in ACA group were significantly higher than that in NC group(all P<0.05). In ACA group, the serum levels of MMP-9 in vulnerable plaque subgroup were significantly higher than that in stabled plaque subgroup(all P<0.05) and the serum levels of MMP-9 in stable plaque subgroup were signiifcantly higher than that in no plaque subgroup(all P<0.05). Conclusion The serum levels of MMP-9 can be serum markers of carotid atherosclerosis plaque and its stability index.%目的：研究基质金属蛋白酶-9（MMP-9）与颈动脉粥样硬化斑块稳定性的关系。方法应用彩色多普勒超声仪探测48例颈动脉硬化患者（颈动脉硬化组）及20例健康体检者（正常对照组）的双侧颈动脉粥样硬化情况，采用酶联免疫吸附法检测各组血清MMP-9水平。结果正常对照组未检出颈动脉粥样硬化斑块。颈动脉硬化组血清MMP-9明显高于正常对照组（P<0.05），颈动脉硬化组中，易损斑块亚组血清MMP-9水平明显高于稳定斑块亚组，稳定斑块亚组血清MMP-9水平明显高于无斑块亚组（均P<0.05）。结论MMP-9水平升高可作为反映颈动脉粥样硬化斑块稳定性的血清学检测指标。