子宫内膜癌组织中RECK与MMP-9的表达及其临床意义

摘要

Objective To study the expression of RECK and MMP⁃9 in endometrial carcinoma and its clinical sig⁃nificance. Methods The endometrial cancer specimens from April 2012 to January 2015 in The First Affiliated Hospital of Luohe Medical College and confirmed by surgery and pathologically were detected by immunohisto⁃chemical S⁃P method to analyze the expression of RECK and MMP⁃9 and their correlation. Results The positive expression rate of RECK gene inendometrial carcinoma was significantly higher than that in control group,35%and 84.4% respectively, and the positive expression rate of group I in endometrial carcinoma was significantly higher than that in groupⅡ⁃Ⅳ,51.4%and 12%respectively, and the difference was significant ( P<0.05) . The positive rate of MMP⁃9 in normal endometrium was significantly lower than that in endometrial carcinoma, 17.8%and 76.7%, respectively. The positive rate of group I in endometrial carcinoma was significantly lower than that in group Ⅱ⁃Ⅳ, 65.7% and 92% respectively, and the difference was significant ( P<0.05) . The expression of MMP⁃9 was negatively correlated with RECK (P<0.05, r=⁃0.390).Conclusion The expression of RECK and MMP⁃9 plays an important role in the occurrence and development of endometrial cancer and has important sig⁃nificance to judge the prognosis.%目的：研究子宫内膜癌组织中RECK与MMP⁃9表达及其临床意义。方法选取于2012年4月至2015年1月期间在漯河医学高等专科学校第一、二附属医院住院手术切除并经病理确诊的内膜癌标本运用免疫组化S⁃P法进行检测，分析RECK和MMP⁃9的表达情况及其相关性。结果 RECK基因在内膜癌阳性表达率明显高于对照组，分别为35�0％和84�4％；内膜癌I期组阳性表达率明显高于Ⅱ⁃Ⅳ期组，分别为51�4％和12�0％，两两比较差异显著（ P＜0�05）。 MMP⁃9在正常内膜阳性率明显低于内膜癌组，分别为17�8％和76�7％；内膜癌I期组阳性率明显低于Ⅱ⁃Ⅳ期组，分别为65�7％和92�0％，二者比较差异显著（ P＜0�05）。 MMP⁃9的表达与RECK呈负相关（ r＝－0�390， P＜0�05）。结论 RECK及MMP⁃9的表达在子宫内膜癌发生发展中发挥一定作用并对预后的判断具有重要的意义。