射血分数保留心力衰竭诊疗进展

摘要

Heart failure( HF) with preserved ejection fraction ( HFPEF) is a clinical syndrome of exercise intol-erance and/or congestion,in the presence of a left ventricular(LV) ejection fraction within the normal limits(i. e.LVEF>50%) .Determining the presence of impaired LV relaxation and/or filling ( diastolic dysfunction ) in HFPEF is needed to pragmatically to distinguish it from other cardiac and non-cardiac conditions where symptoms are not due to HF .There are multiple mechanisms for diastolic dysfunction ranging from structural abnormalities to functional derangements in HFPEF yet tailored therapies are lacking .Treatments proven effective in HF with systolic dysfunction have failed to show significant benefit in patients with HFPEF ,which prognosis remains poor . This review will discuss the HFPEF .%射血分数保留心力衰竭（ HFPEF）是一种运动耐受减低和（或）组织充血为特征的一种临床综合征，而其左心室射血分数在正常范围内（例如LVEF＞50％）。 HFPEF的诊断比射血分数减少心力衰竭（ HFREF）的诊断更具挑战性，因为它需要排除大量其他潜在的提示心力衰竭症状的心源性及非心源性的诊断。舒张功能障碍由多种机制引起，包括心脏结构异常及功能异常，但个体化治疗仍缺乏。随着多年临床治疗发展， HFREF患者的获益明显提高，但是HFPEF患者的患病率及病死率却没有明显改变。