Wig-1 is a transcriptional target of the tumor suppressor p53 and encodes an unusual zinc-finger protein involved in posttranscriptional gene regulation. Wig-1 is expressed in almost all cell types investigated so far,with the highest levels in the brain tissue,and is enriched in stem cells as compared with more differentiated cells of the same lineage. Wig-1 binds to both long double-stranded( ds)RNA and short mi-croRNA-like dsRNA. Wig-1 acts in a positive feedback loop that stabilizes p53 mRNA through an AU-rich element ARE )in 3 'untranslated region of p53 gene. Here is to summarize current knowledge about Wig-1 and discuss its possible role in the tumor,non-neoplastic diseases and stem cells regulation,as well as its implications on p53 function.%Wig-1是抑瘤基因p53的转录调节靶位之一,编码与基因转录后水平调节相关的锌指结构蛋白.Wig-1几乎在所有类型细胞中均有表达,在脑组织中表达水平最高,在干细胞中表达水平较分化细胞高.Wig-1可结合长双链RNA(dsRNA),也可结合短的dsRNA,如microRNA.Wig-1通过结合p53基因3′非翻译区的富于AU元件稳定p53基因mRNA,正反馈调节p53基因.在此讨论Wig-1与p53功能的关系,在肿瘤、非肿瘤性疾病以及干细胞调控中的作用.
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