口服抗糖尿病药物研发新进展

摘要

The study of oral anti - diabetic drug ( OAD ) is continuously progressing in recent years. Thiazolidinediones, glucagon-like peptide-1 receptor activator, dipeptidyl peptidase Ⅳ inhibitors and amylin analogs are already in the market; Glucokinase activator, vanadium complex compounds and bioactive chromium are in study. Besides,the formulations of the existing drugs are also in constant improvement. Gastrointestinal therapeutic system ( GITS ) tablets, sustained - release tablets and complex compounds are emerging gradually. These progresses provide more ways to treat diabetes for better effects.%口服抗糖尿病药物的研发不断取得成功,已经上市的有噻唑烷二酮类、胰高糖素样肽1受体激动剂、二肽基肽酶Ⅳ抑制剂和胰淀素类似物等,正在进行研究的有葡萄糖激酶激活剂、钒复合物和生物活性铬等.原有的药物也在剂型上不断改进,控释剂、缓释剂和复方型逐渐出现.这些研究的成功为糖尿病的治疗提供更多的手段,以期达到更好的治疗效果.