Cisplatin and taxols may cause hyperglycemis. Chemotherapeutic agents interfere with the endocrine axis and the secretion of cytokines and further interrupt the transportation, binding and signaling transduction of hormone , showing an accumulative toxic effect on islet function. Moreover, the metabolic characteristica of malignant tumors are associated with the occurrence of diabetes mellitus. Tumor cella secrete atopic hormones and cytokinea to disrupt the glucose metabolism. Liver and renal dysfunction caused by chemotherapy and some adjuvant drugs are also likely to lead to hyperglycemia. Control of blood glucose favors the tumor treatment, whereas hyperglycemia worsens the condition.%顺铂和紫杉类药物都能引起胰高血糖素升高,化疗药物还干预内分泌轴及细胞因子的分泌,影响激素转运、结合和信号转导,化疗药物对胰岛功能的毒性表现出累积效应.同时恶性肿瘤自身代谢特点与糖尿病发生具有相关性,肿瘤细胞能分泌异位激素及细胞因子进而影响糖代谢,化疗期间受损的肝肾功能及某些辅助药物等因素也能引起血糖升高.高血糖能使肿瘤恶化,而控制血糖对治疗肿瘤有利.
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