目的 探讨乳腺癌术后化疗3个疗程后血清乳腺癌相关抗原(CA153)不同界值对预后评估的意义.方法 选取94例乳腺癌患者,在化疗3个疗程后进行血清CA153测定.分别取30、60和90 U/mL为界值,以累计生存率和平均生存期为参数,绘制卡普兰-梅尔生存曲线,用时序检验法作预后分析.结果血清CA153≤30 U/mL组和＞30 U/mL组患者累计生存率相比较,差异无统计学意义(P＞0.05);≤60 U/mL组和＞60 U/mL组患者累计生存率相比较,差异无统计学意义(P＞0.05);≤90 U/mL组和＞90 U/mL组患者累计生存率相比较,差异有统计学意义(P＜0.05).结论血清CA153以90 U/mL为界值对预后评定有临床价值,对乳腺癌的预后有指导作用.%Objective To investigate the significance of serum CA153 value taken after 3 cycle postoperative chemotherapy for evaluating the prognosis of breast cancer.Methods The patients were divided into three groups according to their serum CA153 concentration such as normal value (30 U/mL) , two fold of normal value (60 U/mL)and three fold of value(90 U/mL ) ，respectively.Accumulated survival rate and average survival time were estimated using Kaplan-Meier estimates and compared with the logrank test where indicated.Results Accumulated survival rate of patients whose 3 cycle postoperative chemotherapy semen CA153 were ≤30 U/mL had no significant difference(P＞ 0.05) from that of CA153 ＞30 U/mL.There was no significant difference ( P ＞ 0.05 ) between the group of CA153 ≤60 U/mL and ＞ 60 U/mL as well.Accumulated survival rate of patients whose 3 cycle postoperative chemotherapy serum CA153 ≤90 U/mL was significantly higher than those whose CA153 ＞ 90 U/mL( P ＜ 0.05 ).Conclusion 90 U/mL of CA153 after 3 cycle postoperative chemotherapy could be applied to evaluate prognosis of breast cancer.
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