目的探讨丹参多酚酸盐对急性脑梗死患者血清C反应蛋白(CRP)水平和血液流变学的影响,并探讨其与临床疗效的关系.方法 将300例符合研究条件的急性脑梗死患者随机分为治疗组和对照组,各150例,对照组患者给予抗血小板聚集、改善脑代谢药物治疗,治疗组在对照组基础上加用丹参多酚酸盐治疗.观察两组治疗前后血清CRP水平和血液流变学的变化及临床疗效.结果 治疗组总有效率明显高于对照组(P＜0.01);CRP浓度较治疗前降低,但治疗组降低较对照更显著(P＜0.05);各组患者治疗后血液流变学指标均有改善,与治疗前比较差异有统计学意义,但治疗组的改善更为明显(P＜0.05).结论 丹参多酚酸盐对抑制病情发展有巨大作用,对治疗急性脑梗死有效,这可能与改善血液流变学、降低血清CRP水平有关.%Objective To evaluate the therapeutic effect of salvianolate for acute cerebral infarction, and to study its infiuenre on hypersensitive C-reactive protein and hemorheological parameters in the peripheral blood of the patients. Methods 300 patients were randomly divided into treatment group and control group, 150 cases each. The control group were treated with conventional drugs and the treatment group were treated with salvianolate on the basis of conventional drugs. The serum concentration of CRP, hemorheological changes and total effective rate before and after treatment were observed. Results After the treatment,the total effective rate in treatment group were higher than that of control group( P ＜0. 01 ). Serum CRP levels of the two groups were both decreased, but the decline in treatment group was more significant than that in control group( P ＜ 0. 05 ). There were statistically significant differences in hemorheological parameters in the patients before and after the treatment in each group, but the difference was more significant in treatment group than in control group( P ＜ 0. 01 ). Conclusion Salvianolate can significantly decrease serum CRP level and improve abnormal hemorheological parameters, which has significant therapeutic effect for acute cerebral infarction.
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