克罗恩病肠壁纤维化的发生机制

摘要

克罗恩病是一种贯穿肠道全层的增殖性疾病,有慢性持续性肠道炎症,各种炎性因子、致纤维化因子等分泌增加,肠间质细胞过度增殖、肠壁上细胞外基质沉积及肠道肌层过度生长,肠壁组织结构紊乱并明显增厚,导致肠壁纤维化形成.肠壁纤维化是克罗恩病最严重的并发症之一,目前尚无较好的治疗方法,有待于对其发生机制进一步研究,为临床治疗提供线索.%Crohn's disease is a chronir and persistent inflammatory bowel disease throughout ail the intestinal layers,featured with various iniiammatoiy factors and the librosis fartors secretion increase,intestinal mesenchymal cells over-proliferation, the extracellular matrix deposits on the bowel wall and intestinal muscle layer excessive growth,intestinal wall structure disorder with the bowel wall obvious thickening,which cause the intestinal librosis,which is one of the most serious complications. Currently there is no good therapies, calling lor future study on the genesis mechanism to provide clues lor the clinical treatment.