低氧微环境是实体肿瘤共有的一个重要特征,影响着肿瘤的进展和预后.缺氧诱导因子(HIF-1)在实体肿瘤中呈普遍高表达,肿瘤细胞在HIF-1的转录调控下适应低氧环境.HIF-1通过激活靶基因使其在肿瘤发展、侵袭和转移中发挥着重要作用,导致肿瘤常规治疗预后较差.因此,研究HIF-1与肿瘤之间的关系显得尤为重要.现就HIF-1的概况、靶基因及其与肿瘤血管生成、能量代谢、侵袭转移、生存增生和凋亡关系予以综述.%Hypoxic microenvironment is an important common feature of solid tumors, which influences tumor progression and prognosis. Studies have shown that overexpression of the Hypoxia-inducible Factor-1 ( HIF-1 )has been observed in many human cancers and the major mechanism of the adaptation of cancer cells to their hypoxic microenvironment is the regulation of transcription HIF-1. HIF-1 plays a central role in tumor progression,invasion,and metastasis through activating the target genes,and it triggers off a poor prognostic outcome of conventional treatments. Therefore, it is particularly important to study on the relationship between HIF-1 and human tumors. Here is to make a review on the basic information and the target genes of HIF-1 ,and its correlation with angiogenesis,energy metabolism,invasion and metastasis,proliferation and ap-optosis of the tumors.
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