特异性溶瘤腺病毒治疗膀胱癌的研究进展

摘要

溶瘤腺病毒因能够杀伤膀胱癌细胞同时对正常组织几乎没有影响而受到人们的广泛关注，对其进行了多方面的研究，其中特异性启动子调控的溶瘤腺病毒是研究热点。人们通过插入单个或多个特异性启动子构建了治疗膀胱癌的组织特异性溶瘤腺病毒来提高其靶向性、特异性和安全性。现就特异性启动子调控溶瘤腺病毒治疗膀胱癌的原理、研究进展以及存在的问题等方面进行综述。%Oncolytic adenovirus have caused extensive concern,because they can kill bladder cancer but almost no effect on normal tissues,have been studying in many ways. In these studies,oncolytic viruses regula-ted by specific promoter is a hot area. People construct many kinds of oncolyitc adenovirus by inserting single or multipl specific promoters to take researches of treating bladder cancer in order to make these have better speci-ficity,targeting and safety. This article reviewed the status of bladder cancer's treatment,introduced the princi-ple,the advancement,the problems and prospects of oncolytic viruses regulated by specific promoter treated bladder cancer.