乙型肝炎表面抗原定量检测技术与乙型肝炎病毒DNA相关性研究进展

摘要

Hepatitis B surface antigen(HBsAg) is a sign of hepatitis B virus(HBV) infection,HBsAg quantitatification can be used to monitor and predict the curative effect of antiviral therapy. HBV DNA is the most direct index to detect HBV replication and infectivity,with high specificity and sensitivity. In clinical antiviral efficacy was assessed by detecting HBsAg and HBV DNA level to guide and adjust the therapy plan. There are a number of reports about the correlation of HBsAg and HBV DNA,and the study is to elucidate different factors affecting the change of HBsAg and HBV DNA and the relevance.%乙型肝炎表面抗原(HBsAg)是乙型肝炎病毒(HBV)感染的标志,HBsAg定量能监控和预测患者抗病毒治疗的疗效。 HBV DNA是检测HBV有无复制及传染性最直接、特异性强和灵敏性高的指标。临床往往通过监测HBsAg和(或) HBV DNA定量水平,评估抗病毒疗效,指导、调整治疗方案。目前有关HBsAg与HBV DNA的相关性报道较多,该研究重点阐明在不同因素影响下HBsAg与HBV DNA的变化情况及关联性。