四次跨膜超家族蛋白3在肿瘤中的研究进展

摘要

Taransmembrane 4 superfamily 3(TM4SF3),also known as CO-029,TSPAN8 and D6.1A(in rats),is a member of transmembrane 4 super family.TM4SF3 overexpression has been reported in many digestive system neoplasms such as colorectal cancer,hepatic cancer,esophageal cancer and pancreatic canc-er, and its expression is associated with poor prognosis of patients with digestive system neoplasms .TM4SF3 promotes the tumor growth and metastasis possibly by inducing angiogenesis and enhancing the tumor cell mi-gration.Here is to make a review of the researches about the TM4SF3 effect in tumors and the molecular bio-logical mechanisms.%四次跨膜超家族蛋白3（TM4SF3），又称为CO－029、TSPAN8，在大鼠中被称为 D6．1A，是四次跨膜超家族（TM4SF）中的一员。 TM4SF3在结直肠癌、肝癌、食管癌及胰腺癌等多种消化系统肿瘤中存在高表达，其表达与消化系统肿瘤患者的不良预后密切相关。 TM4SF3可能通过促血管再生、增强肿瘤细胞迁移等促进肿瘤的转移与进展。该文旨在对 TM4SF3在肿瘤中的作用及其分子生物学机制等方面的研究进展予以综述。