酒精性心肌病发病机制的研究进展

摘要

酒精性心肌病（ ACM）是现代心血管领域一种日益增多的疾病。但对其确切发病机制的了解还几近空白，对此进行研究具有重要的临床预防与治疗意义。 ACM 的发病常伴有心脏扩大、心律失常和心力衰竭等并发症。 ACM 的发病机制与氧化应激、心肌能量代谢紊乱、肾素－血管紧张素系统激活、心肌重构、心肌纤维化等有关。心肌能量代谢紊乱与氧化应激拥有潜在的研究价值和抗氧化疗法可能的临床应用价值。%Alcoholic cardiomyopathy(ACM) is a kind of cardiovascular diseases with a growing number of patients in modern cardiovascular field.The exact pathogenesis of ACM is nearly blank.The onset of ACM is often accompanied by cardiac enlargement,cardiac arrhythmia and heart failure.The pathogenesis of ACM is related to oxidative stress,dysfunction of myocardial energy metabolism,activation of the renin-angiotensin system,myocardial remodeling,and myocardial fiber.Dysfunction of myocardial energy metabolism and oxida-tive stress are two directions with potential research value,and antioxidants could be an alternative therapy in the clinical treatment of ACM.