急性脑梗死患者血清同型半胱氨酸及血脂水平分析

摘要

目的：探讨急性脑梗死患者血清同型半胱氨酸（ Hcy）和血脂的水平，为急性脑梗死的早期诊断提供理论依据。方法选取驻马店市中心医院2012年8月至2013年12月收治的急性脑梗死患者50例为急性脑梗死组，并选取同期进行健康体检的正常者50例为对照组，测定两组人群的Hcy 及血脂水平，比较两组 Hcy 及血脂指标的阳性率。结果急性脑梗死组患者血清 Hcy、低密度脂蛋白胆固醇（LDL－C）、三酰甘油（TG）、总胆固醇（ TC）的水平均显著高于对照组（ P ＜0.05），而高密度脂蛋白胆固醇（HDL－C）水平显著低于对照组（ P ＜0.05）；急性脑梗死组患者 TG、TC、Hcy、HDL－C及 LDL－C 阳性率显著高于对照组（P ＜0.05）。结论急性脑梗死患者血清 Hcy 和血脂水平会发生变化，定期测定血清中 Hcy 和血脂水平有助于早期诊断急性脑梗死，从而有效预防、治疗及控制急性脑梗死的发生。%Objective To explore the levels of serum homocysteine (Hcy) and blood fat of acute cere-bral infarction,in order to provide basis for early diagnosis.Methods Total of 50 patients with acute cere-bral infarction and 50 cases of healthy were selected in Zhumadian center hospital from August 2012 to December 2013,and named as the observation group and control group respectively.Then the Hcy,blood fat levels and the positive rates of Hcy and blood fat in both groups were measured.Results Compared with the control group,serum Hcy, low density lipoprotein-cholesterol ( LDL-C),trigalloyl glycerol ( TG) and total cholesterol (TC)level increased significantly in cerebral infarction group (P <0.05),high density lipopro-tein cholesferol (HDL-C) level decreased significantly ( P <0.05).Compared with the control group,the positive rates of TG,TC,Hcy,LDL-C and HDL-C were higher in cerebral infarction group ( P <0.05) . Conclusion Hcy levels in patients with acute cerebral infarction and serum lipid level changes,regular measurement of Hcy and serum lipid level is helpful in the early diagnosis of acute cerebral infarction,and effective prevention,treatment and control of acute cerebral infarction.