癌症恶病质发病机制与治疗研究进展

摘要

癌症恶病质（ CC）是晚期恶性肿瘤常见并发症。近十年，尽管 CC 发生机制的研究取得了一些新进展，但其治疗尚缺乏理想的方法。 CC病理生理机制复杂，涉及系统性炎症反应、脂肪代谢和蛋白质代谢等多种因素。 CC的成功治疗也有赖于多途径干预，包括营养支持和多种药物联合运用。目前临床上用于治疗CC的药物有沙利度胺、非甾体消炎药类、孕酮类等；另外，一些根据其发病机制设计的新药尚处于临床研究阶段（如ALD518、OHR／AVR118等）。%Cancer cachexia is a common complication of advanced cancer.Over the last decade,we have gained new insight into the pathophysiology of cancer cachexia.Unfortunately,its treatment remains a chal-lenge.Cancer cachexia is a multifactorial syndrome,which is mainly related to systemic inflammatory reac-tion,lipid metabolism and protein metabolism ,etc.The successful management of cancer cachexia will likely require the multimodal approaches that include nutritional support and combination of pharmaceutical inter-ventions.The current drugs in clinic for treatment of cancer cachexia include thalidomide,nonsteroid anti-inflammatory drugs,progesterone drugs,etc.In addition,some new drugs designed according to the cancer cachexia pathogenesis are still in the clinical research stage,such as ALD518,OHR/AVR118,etc.