脂联素在风湿性疾病中的免疫调节作用

摘要

脂肪组织以内分泌、旁分泌、自分泌的形式分泌大量的生物活性物质——脂肪因子,其包括瘦素、脂联素、内脂素、胰岛素样生长因子1、白细胞介素6等.其中,脂联素由脂肪细胞分泌并在脂肪组织中大量表达,它以内分泌的形式循环于血液中,具有调节物质代谢及抵抗炎症的作用,但具体机制尚不明确.脂联素在风湿性疾病中发挥重要作用,它不仅在很多风湿性疾病患者的血清或关节液中表达异常,还与疾病的发生、发展及疾病活动度具有相关性.因此,对脂联素的进一步研究将为风湿性疾病的治疗提供新思路与途径.%Adipose tissue secrets a large number of bioactive substances-adipocytokines,including leptin,adiponectin,visfatin,insulin-like growth factor-1,interleukin-6 and so on,by endocrine,paracrine,and autocrine.Among them,adip onectin is secreted by adipocytes and is abundantly expressed in adipose tissue,which circulates in the blood by endocrine,with the function of regulation of metabolism and resistance to inflammation,though the specific mechanism is not clear.Adiponectin plays an important role in rheumatic diseases,which is not only abnormally expressed in the serum or synovial fluid of many patients with rheumatic diseases,but is also associated with the occurrence,development and activityof the disease.Therefore,further study of adiponectin will provide new ideas and pathways for the treatment of rheumatic diseases.