细胞自噬可通过溶酶体吞噬降解自身结构,分为大自噬、小自噬和分子伴侣介导自噬,具有广泛的生物学作用.细胞自噬在肿瘤的发生、发展过程中起双重调节作用,既可对肿瘤细胞产生抑制作用,又可促进其发生和发展,肿瘤细胞可释放特定的信号分子来诱导间质细胞自噬,而此过程中所产生的营养物质又为肿瘤细胞的生长、繁殖和转移提供了必要的基础和条件.%Autophagy is a programmed cell process widely existing in eukaryotic cells death by lysosomal to degrade itself,and can be divided into small autophagy,autophagy and chaperone mediated autophagy,which has extensive biological functions.Autophagy plays dual role in the process of tumor progression,which can both inhibit the growth of tumor cells,and promote the occurrence and development,that tumor cells can release specific signaling molecules to induce mesenchymal cell autophagy,which produces nutrients to provide a basis and necessary conditions for the reproduction,growth and transfer of tumor cells.
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