Mdm2转录产物对p53调节作用的研究进展

摘要

One of the most important proteins in tumor biology is p53,also called " the guardian of the gene",and serves as a cornerstone in the cellular response to stress and particular in the defense against malignant transformation.Murine double minute 2(Mdm2) is an oncoprotein that blocks p53 tumor suppressor-mediated transcriptional transactivation,and the mdm2-fl is highly expressed in most tumor cells.Splice variants are also highly expressed in most tumor cells,such as Mdm2-a,Mdm2-b,Mdm2-c.Mdm2 and p53 interaction is associated with the occurrence and development of tumors.It should not be ignored that Mdm2 splice variants has a crucial influence on mediating p53 as Mdm2 and p53 become the research hotspot.%在肿瘤生物学中,p53是最重要的蛋白质之一,这种蛋白又称“基因守护者”,作为一种细胞内应激反应的基础,在抑制肿瘤中有重要的作用.鼠双微体2(Mdm2)是一种肿瘤蛋白,有抑制p53肿瘤抑制因子介导的转录激活的作用,而且在肿瘤细胞中高表达.除全长Mdm2(mdm2-fl)高表达外,Mdm2其他转录产物,如Mdm2-a、Mdm2-b、Mdm2-c,在肿瘤细胞中也存在高表达.肿瘤的发生及发展与Mdm2和p53之间相互作用有关,在Mdm2与p53研究成为热点的同时,Mdm2其他转录产物对p53影响也是至关重要.