Neuropilin-1及配体Semaphorin3 A在糖尿病肾病中的作用进展

摘要

糖尿病肾病(DN)是糖尿病中相对严重的微血管并发症,也是糖尿病患者死亡的主要原因.目前DN的发病机制尚不完全明确,多种机制参与了DN的发生、发展.Neuropilin-1具有促进血管生成及抑制细胞迁移等作用,而Semaphorin3A参与器官的发生、肿瘤的形成以及免疫反应等.在糖尿病患者中,Neuropilin-1及配体Sema-phorin3A通过影响细胞外基质形成、足细胞数量及黏附功能、肾小球基膜形成等,导致蛋白尿形成,进而促进DN的发生、发展.了解Neuropilin-1及配体Semaphorin3A具体的作用机制有助于DN的治疗.%Diabetic nephropathy ( DN) is a relatively serious microvascular complication in diabetes mellitus ,which is the main cause of death in diabetic patients .At present ,the pathogenesis of DN is not fully known ,and a variety of mecha-nisms are involved in the occurrence and development .Neuropilin-1 can promote angiogenesis and inhibit the migration of cells.Semaphorin3A is related to organogenesis ,tumor formation and immune response .Neuropilin-1 and ligand Semaphor-in3A can promote the formation and development of DN by affecting the podocyte adhesion and number ,formation of extra-cellular matrix and glomerular basement membrane .Understanding the mechanisms will contribute to DN treatment .