核转录因子Nrf2是细胞抗氧化应激体系中的关键转录因子,Nrf2核转位并且结合核酸序列上的抗氧化反应元件ARE是活化Nrf2-ARE信号通路的关键环节. 而Nrf2-ARE信号通路的活化,能够启动下游的Ⅱ相解毒酶、抗氧化酶系等的转录,从而减轻活性氧和亲电子物质引起的细胞损伤,使细胞处于稳定状态,维持机体氧化还原动态平衡. Nrf2-ARE信号通路在细胞氧化应激损伤防护中发挥重要作用. 本文就Nrf2-ARE信号通路对机体氧化应激损伤防护的研究进展进行综述.%The nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is a key transcription factor of cell anti-oxi-dative stress system, and Nrf2 nuclear translocation combined with anti-oxidative response element antioxidant responsive element ( ARE) on the nucleic acid sequence is a key link in the process of activation of Nrf2-ARE signaling pathways. The activation of Nrf2-ARE signaling pathway can start the transcription of the downstream phase Ⅱ detoxification en-zymes and antioxidant enzymes so as to reduce the cell injuries caused by reactive oxygen and electronic materials, keep the cells in a stable state, and maintain the body''''''''''''''''''''''''''''''''s redox in dynamic balance. Nrf2-ARE signaling pathway plays an im-portant role in the protection of cell oxidative stress injury. The paper summarizes the progression of Nrf2-ARE signaling pathway in protection of oxidative stress injury of the body.
展开▼
