Objective To investigate clinical effects of Propess and COOK hyponome induced cervical ripening in application of induction delivery during late trimester of pregnancy. Methods A total of 212 pregnant women in late trimester of pregnancy during June 2012 and June 2013 were divided into the Propess group (n = 106) and the COOK hy-ponome group (n = 106) according to inducing methods. The total effective rate, delivery methods, the duration from in-tervention to preliminary labor, the total stage of labor, postpartum hemorrhage volume and newborns conditions in the two groups were observed. Results In the COOK hyponome group, the total effective rate and vaginal parturition rate were higher, and the first and second stages of labor, and the total stage of labor were longer, and the postpartum hemorrhage volume was less than those in the Propess group (P < 0. 05), and there was no statistically significant difference in Apgar score in the two groups (P > 0. 05), and there were no serious complications in the two groups. Conclusion Propess and COOK hyponome are safe and effective in application of induction delivery during late trimester of pregnancy, and clinicians should choose appropriate inducing method based on the idiographic conditions.%目的：探讨普贝生和 COOK 水囊应用于妊娠晚期引产促宫颈成熟的临床效果。方法选择2012年6月—2013年6月收治的妊娠晚期孕妇212例，根据引产方法分为普贝生组和 COOK 水囊组，每组106例。观察两组总有效率、分娩方式、干预至临产时间、总产程、产后出血量及新生儿情况。结果 COOK 水囊组总有效率、阴道分娩率高于普贝生组，第一、二及总产程长于普贝生组，产后出血量少于普贝生组(P <0．05)。两组新生儿 Apgar 评分比较差异无统计学意义(P >0．05)，均未发生严重并发症。结论两种方法用于妊娠晚期引产均安全、有效，临床应根据具体情况选择合适的引产方法。
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