目的：研究应用6%纳米二氧化硅改性氰基丙烯酸酯抗菌胶的抗菌性能。方法采用滤纸片法测试6%纳米二氧化硅/抗菌胶对金黄色葡萄球菌( ATCC29213)的抑菌性能,以未改性的抗菌胶作为对照,测量抑菌圈直径。制作大鼠外伤动物模型,分别用6%纳米二氧化硅抗菌胶及纱布包扎处理伤口,观察伤口的大体情况,并做动脉血常规及创面组织病理切片检测白细胞计数。结果6%纳米二氧化硅/抗菌胶组第5天的抑菌圈直径为(28.61±0.91)mm,抗菌胶组为(28.24±2.69)mm,两组比较差异无统计学意义(P>0．05)。动物实验方面,在血常规及创面组织病理切片中,6%纳米二氧化硅/抗菌胶处理创面的感染情况均低于纱布包扎组(P<0.05)。结论6%纳米二氧化硅改性的抗菌胶具有较好的抗菌性能(抗金黄色葡萄球菌)。%Objective To study the antimicrobial function of Cyanoacrylate antimicrobial adhesive modified by modified. Methods Antimicrobial function to staphylococcus aureus ( ATCC29213 ) of cyanoacrylate antimicrobial ad-hesive modified 6% nano-silica was examined with filter paper method, while unmodified antimicrobial adhesive was used as a control group, and the diameter of the inhibition zone was detected. The rat models of external injury were estab-lished, and then the wounds were treated with 6% nano-silica antimicrobial adhesive and gauze bandage respectively. The general conditions of wounds were observed, and routine blood tests and pathological sections were performed to cal-culate white blood cell count ( WBC) . Results The diameter of inhibition zone in antimicrobial adhesive modified 6%nano-silica group on 5th d after treatment was (28. 61 ± 0. 91) mm, while the diameter in control group was (28. 24 ± 2. 69) mm, but the difference was not statistically significant (P<0. 05). The blood routine tests and pathological sec-tions showed that 6% nano-silica or antimicrobial adhesive had a lower infection rate than that by gauze bandage ( P<0. 05). Conclusion The Cyanoacrylate antimicrobial adhesive modified by 6% nano-silica has a good antimicrobial function ( resistant staphylococcus aureus) .
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