Objective To observe effects of Fuzheng Xiaoying Decoction on serum thyroglobulin ( TG) and toxic side effect of 131 I + thyroid stimulating hormone ( TSH) inhibition treatment in adjuvant therapy of patients with thyroid carcinoma after operation. Methods A total of 84 thyroid carcinoma patients after operation admitted during April 2014 and June 2016 were divided into observation group (n=42) and control group (n=42) according to therapeutic meth-ods. Control group was treated with 131 I + L-Thyroxine Sodium Tablets, while observation group was treated with Fuzheng Xiaoying Decoction on the basis of treatment for control group, and two groups were treated for 2 cycles. Clinical data of the selected patients was retrospectively analyzed, and comparative analysis was also performed for analyzing conditions of serum TG and toxic and side effect. Results After treatment, TG levels were significantly lower than those before treat-ment in two groups (P<0. 05), and the level in observation group was significantly lower than that in control group (P<0. 01);in observation group, the proportion of TG normal recovery was significantly higher, while the proportion of ab-normal TG was significantly lower than those in control group (P<0. 05). After the second cycles of treatment, symptom scores of toxic side effect were significantly higher than those after the first cycle of treatment in two groups (P<0. 05), and the score in observation group was significantly higher than that in control group (P<0. 05). In observation group, improved proportion of symptom scores of toxic side effect was significantly higher, while general and poor proportion was significantly lower than those in control group (P<0. 05). Conclusion Fuzheng Xiaoying Decoction in adjuvant thera-py of patients with thyroid carcinoma after operation may significantly reduce postoperative TG level and incidence rate of toxic side effect induced by postoperative 131 I + TSH inhibition treatments simultaneously, and improve clinical symptoms and safety.%目的 观察分析扶正消瘿汤辅助治疗对甲状腺癌术后患者血清甲状腺球蛋白(TG)和131 I、促甲状腺激素(TSH)抑制治疗毒副反应的影响.方法 选取2014年4月—2016年6月收治的84例甲状腺癌术后患者进行研究,按照治疗方式分为观察组与对照组,每组42例.对照组采用131 I、左甲状腺素钠片治疗,观察组在对照组基础上联合扶正消瘿汤治疗,两组共治疗2个周期.回顾性分析所选患者的临床资料,对比分析治疗后血清TG和毒副反应情况.结果 治疗后,两组TG水平低于治疗前(P<0.05),观察组低于对照组(P<0.01);观察组TG水平恢复正常比例高于对照组,异常比例低于对照组(P<0.05).第2周期治疗后,两组毒副反应症状积分高于第1周期治疗后(P<0.05),且观察组明显高于对照组(P<0.05);观察组毒副反应症状积分好转比例高于对照组,一般和不佳比例低于对照组(P<0.05).结论 甲状腺癌术后患者采用扶正消瘿汤进行辅助治疗,可以明显降低TG水平,同时能降低术后131 I、TSH抑制治疗引起的毒副反应,改善患者临床症状,提高治疗的安全性.
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