目的:研究C-反应蛋白、白细胞介素6 (IL6)、血清前白蛋白及血常规联合检验在小儿细菌性感染性疾病诊断中的应用价值.方法:本次研究于医院儿科选取2016年11月~2017年12月收治的200例小儿细菌性感染性疾病患者、 200例小儿非病菌性感染疾病患者和同期200例体检康康儿童进行研究,将三组分别设为细菌组、非细菌组和对照组,对三组皆实施C-反应蛋白(CRP)、白细胞介素6 (IL6)、血清前白蛋白(PA)及血常规检查,对比不同检查方式的诊断准确率.结果:细菌组的CRP、 IL6和WBC水平均明显高于非细菌组和对照组(P＜0.05);细菌组的PA水平显著低于非细菌组和对照组(P＜0.05); CRP、 IL6、 PA和WBC联合检查的诊断准确率高于CRP、 IL6、 PA和WBC单独检查的诊断准确率(P＜0.05).结论:细菌性感染性疾病患儿的CRP、 IL6、 PA和WBC水平与非细菌性感染性疾病患儿及健康儿童具有显著的差异, CRP、 IL6、 PA和WBC联合检查的诊断准确率显著高于CRP、 IL6、 PA和WBC单独检查的诊断准确率,具有较高的临床诊断价值.%Objective: To study the value of combined detection of C-reactive protein, interleukin 6 (IL 6) , serum prealbumin and blood routine in the diagnosis of bacterial infections in children. Methods: in this study, 400 pediatric patients with bacterial infections were selected from November 2016 to December 2017. 400 children with non-bacterial infections and 400 healthy children with physical examination during the same period were studied. Patients were divided into three groups: bacterial group, non-bacterial group and control group. All three groups were treated with C-reactive protein (CRP) , interleukin-6 (IL-6) and serum prealbumin. Protein (PA) and blood routine examination were used to compare the diagnostic accuracy of different examination methods. Results: the levels of CRPnIL6 and WBC in bacterial group were significantly higher than those in non-bacterial group and control group (P<0.05) , the PA level in bacterial group was significantly lower than that in non-bacterial group and control group ( P<0.05) . The diagnostic accuracy of combined examination of CRP and IL6PA and WBC was higher than that of single examination of CRP and IL6 and WBC (P<0.05) . Conclusion:The levels of CRPnIL6PA and WBC in children with bacterial infectious diseases were higher than those in children with non-bacterial infectious diseases. The diagnostic accuracy of combined examination of CRPnIL6PA and WBC in healthy children was significantly higher than that in CRPnIL6PA and WBC alone, which was of high clinical diagnostic value.
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