β2-微球蛋白、癌胚抗原和D-二聚体联合检测在恶性肿瘤诊断中的应用

摘要

Objective:The changes ofβ2- microglobulin (β2- MG) , carcino- embryonic antigen (CEA) and D- Dimer in patients with malignant tumor were detected, and the clinical significance of combined detection was discussed. Methods: The levels of serum β2- MG, CEA, and D- Dimer in 245 patients with malignant tumor ( cancer group) from 2014 to 2015 were analyzed and compared with the 200 cases of healthy control group. Results: Compared with the healthy control group, the serum levels ofβ2- MG, CEA and D- Dimer in cancer group were significantly higher, and the positive rate of the three joint detection was higher than that of single item ( <0.05) . Conclusion: The combined detection of serum β2- MG, CEA and D- Dimer has important clinical value for early screening and diagnosis of malignant tumor patients.%目的：对恶性肿瘤患者的β2-微球蛋白（β2- MG）、癌胚抗原（CEA）及D-二聚体(D- Dimer)的变化进行研究，并探讨联合检测的临床意义。方法：选取2014年至2015年本院收治的245例恶性肿瘤患者（癌症组）的血清β2- MG、CEA及D- Dimer含量与200例健康对照组进行分析比较。结果：与健康对照组比较，癌症组的血清β2- MG、CEA及D- Dimer含量均明显增高，三者联合检测阳性率高于单一项目检测(<0.05)。结论：血清β2- MG、CEA及D- Dimer联合检测对恶性肿瘤患者的早期筛查诊断具有重要的临床价值。